Staff Mass Spectrometrist — Universität Zürich

Full description

The University of Zurich, Switzerland's largest university, offers a range of attractive positions in various subject areas and professional fields. With around 10,000 employees and currently 12 professional apprenticeship streams the University offers an inspiring working environment on cutting-edge research and top-class education. Put your talent and skills to work with us. Find out more about UZH as an employer!

Aufgaben

• You operate and maintain the mass spectrometry infrastructure, including Orbitrap Astral instruments and supporting LC systems, ensuring consistently high performance.
• Coordination, preparation, and processing of biological samples for stable isotope tracing, metabolomics, epitranscriptomics, and other MS-omics analyses - including low-input and single-cell samples - are part of your responsibilities.
• You support the implementation of automated sample preparation pipelines to increase throughput and improve reproducibility.
• Hands-on guidance and training of students and postdocs in the use of the instruments is an important part of your role.
• You actively contribute to the development and optimization of LC-MS methods for metabolite quantification, isotope enrichment, lipid profiling, and modified nucleotides.
• Routine instrument calibration, troubleshooting, and preventive maintenance are carried out by you independently.
• You support data acquisition as well as initial QC and processing pipelines.
• You perform MS data processing and analysis across applications and collaborative projects, ensuring high data quality and consistency.
• You manage MS data across projects to ensure traceability, organization, and -reproducibility.
• You also help manage consumables, sample logistics, and platform documentation.

Anforderungen

• Expert (MSc or PhD) in analytical chemistry, biochemistry, or a related field
• Solid practical experience with LC-MS/MS - ideally on Orbitrap-based instruments
• Background in stable isotope tracing and/or metabolomics in a biological setting is strongly preferred
• Interest in or experience with laboratory automation - liquid handling, automated sample prep, or scripted workflows
• Curiosity about emerging technologies, particularly single-cell mass spectrometry, is a genuine plus
• Methodical, detail-oriented, and comfortable troubleshooting complex instrument issues
• Able to work independently and communicate clearly with researchers at all levels
• Experience in a core facility, CRO, or research lab environment is valued
• English required
• German is a plus

Wir bieten

Our employees benefit from a wide range of attractive offers. Find out more: https://www.uzh.ch/de/explore/work.html.