Director, Translational Medicine Expert (Neurodegeneration) — Novartis
- Location
- Basel
- Contract
- full-time
- Posted
- Today
Role overview
Salary Range
CHF150,500.00
CHF279,500.00 Job Description Summary LI-Hybrid Internal job title: Director Location: Basel, Switzerland
- Salary Range:
- CHF150,500.00
- Key Responsibilities:
- Translational Strategy & Program Leadership
Main responsibilities
- Key Responsibilities:
- Translational Strategy & Program Leadership
- Define and execute integrated translational strategies across neurodegeneration programs
- Lead translational components from preclinical → Phase 1/2 clinical studies
- Drive program progression through key decision gates (e.g., IND, TDP, IDPA)
- Ensure strong mechanistic linkage between target biology, biomarkers, and clinical endpoints Biomarker & Endpoint Leadership
- Collaborate with Biomarker Development colleagues toward development and validation of:
- Molecular biomarkers (tissue, blood, CSF where applicable)
- Functional endpoints (strength, mobility, disease-specific measures) Patient-reported outcomes (PROs)
- Establishing quantitative biomarkers to support: Target engagement Disease modification Dose selection and PoC decisions
Company and context
- Drive alignment between research, TM, and development organizations External Scientific Leadership Build and lead collaborations with: Academic KOLs
- Patient advocacy groups (critical in rare neuromuscular disease)
- Technology partners (imaging, omics platforms)
- Contribute to scientific strategy and external positioning of programs Patient-Centered Development
- Integrate the patient voice into translational and clinical strategies Advance: Meaningful functional endpoints Patient-relevant outcome measures
- Innovative trial approaches (e.g., decentralized models where feasible) Portfolio Contribution & Strategic Input Contribute to:
- Asset prioritization and portfolio strategy
- Competitive differentiation strategy (e.g., vs RNA or gene therapy competitors) Provide scientific input to: Business development / due diligence Indication expansion strategies Essential Requirements:
- MD, neurologists, clinical training in neurodegenerative diseases
- Experience in translational medicine, early clinical development, or experimental therapeutics.
Additional details
- Job Description Summary Internal job title: Director Location: Basel, Switzerland
- Support new and ongoing clinical research and clinical trials and ensure efficient and timely processing of confidentiality agreements and clinical agreements
- Ensure strong mechanistic linkage between target biology, biomarkers, and clinical endpoints Biomarker & Endpoint Leadership
- Functional endpoints (strength, mobility, disease-specific measures) Patient-reported outcomes (PROs)
- Establishing quantitative biomarkers to support: Disease modification Dose selection and PoC decisions
- Drive early biomarker de‑risking , a key priority in neuromuscular programs Early Clinical Development (Phase 1/2)
- Co‑lead design and execution of early clinical studies Dose escalation strategy Exposure–response framework
- Ensure TM leadership within Clinical Trial Teams (CTTs) for: Execution oversight Data interpretation and decision-making Cross-Functional Leadership
- Serve as core Translational Medicine representative within global project teams Partner closely with: Clinical Development Biomarker Development Clinical Pharmacology (PKS) Preclinical Safety (PCS)
- Drive alignment between research, TM, and development organizations External Scientific Leadership Build and lead collaborations with:
Notes and original content
- CHF279,500.00
- Job Description Summary
- Internal job title: Director
- Location: Basel, Switzerland
- Job Description
- Ensure strong mechanistic linkage between target biology, biomarkers, and clinical endpoints
- Biomarker & Endpoint Leadership
- Functional endpoints (strength, mobility, disease-specific measures)
- Patient-reported outcomes (PROs)
- Establishing quantitative biomarkers to support:
Questions about this listing
What salary does Novartis offer for this role?
Novartis lists CHF 85'500 - 129'500 gross per year for this position in Basel. This is the salary published in the original listing (or, when the employer omits a figure, a realistic estimate for the role and sector) — the calculator on this site converts it to your actual net take-home once cross-border tax and social contributions are applied.
Is this a full-time role, and what type of contract does Novartis offer?
This listing is a full-time position. The contract type shown here comes directly from the employer's original posting; always confirm exact hours, notice period and probation length with Novartis during the application process, since these details can vary by role even within the same contract category.
Do I need a cross-border work permit for a role in Basel?
EU/EFTA residents living in the border zone of the country adjoining Canton Basel can apply for a G permit; the Swiss employer files it with that canton's migration office after the contract is signed. Border-zone rules and processing times vary by neighbouring country and canton, so confirm the specifics with Basel's cantonal migration office or with HR during the application.
How do I apply for this position at Novartis?
Use the "Apply now" button on this page — it links directly to Novartis's original listing at novartis.wd3.myworkdayjobs.com, so your application goes straight to the employer's own applicant-tracking system. Frontaliere Ticino does not collect or forward applications itself.
