PostDoctoral Position : Image-Based Drug Screening Against Bacterial Pathogens — EPFL
- Lieu
- Lausanne
- Contrat
- full-time
- Publié
- Hier
Vue d’ensemble du poste
Mission A postdoctoral position is available in the laboratory of Prof.
Alex Persat (EPFL School of Life Sciences, https://www.p-lab.science/ ) to establish a new image-based drug screening platform targeting gram-negative pathogens ( Klebsiella pneumoniae , Acinetobacter baumannii , Pseudomonas aeruginosa ).
The project will combine single-cell/single-bacterium imaging approaches with the lab's tissue-engineered infection models to identify and characterize compounds active against these priority pathogens.
- Mission A postdoctoral position is available in the laboratory of Prof.
- Alex Persat (EPFL School of Life Sciences, https://www.p-lab.science/ ) to establish a new image-based drug screening platform targeting gram-negative pathogens ( Klebsiella pneumoniae , Acinetobacter baumannii , Pseudomonas aeruginosa ).
- Main duties and responsibilities
- Design and build a microscopy-based phenotypic screening pipeline (live imaging, high-content, single-cell resolution) to assay compound activity
Responsabilités principales
- Main duties and responsibilities
- Design and build a microscopy-based phenotypic screening pipeline (live imaging, high-content, single-cell resolution) to assay compound activity
- Develop imaging assays capable of distinguishing mechanism of action (e.g. growth inhibition, biofilm/attachment disruption, membrane integrity)
- Develop or adapt image analysis and quantification pipelines with AI support to handle screen-scale data
- Follow up on screening hits to identify their molecular target or mechanism of action (e.g. via genetic, chemical-biology, or biophysical approaches), with support from other lab members' expertise in microbiology and drug discovery
- Collaborate with the lab's discovery and design efforts (natural products, AI-enabled molecular design) to feed prioritized targets and hits back into upstream design
Processus de candidature
- the pipeline to screens in both standard culture and, in collaboration with other lab members, the group's organoid/tissue-engineered infection models (airway, gut) to prioritize physiologically relevant hits
- Co-supervise PhD students and contribute to method development, data management, and grant reporting Profile
- PhD in microbiology, biophysics, bioengineering, or a related field (completed or near completion) with at least a first author publication.
- Hands-on experience with quantitative microscopy (live-cell imaging, high-content screening, or single-cell/single-bacterium imaging)
- Comfort with image analysis pipelines and scripting (Python), experience integrating ML-based image analysis is a plus but not required
- Interest in working across the interface of imaging, microbiology, and drug discovery We offer
- The opportunity to build a new screening platform from the ground up, with significant ownership over pipeline design
- Access to the lab's existing imaging/biophysics infrastructure and tissue-engineered infection model systems
Contacts
- For informal inquiries, contact: [email protected]
Détails supplémentaires
- details for 3 referees Additional information Contract start date: negotiable A postdoctoral position is available in the laboratory of Prof.
- Apply the pipeline to screens in both standard culture and, in collaboration with other lab members, the group's organoid/tissue-engineered infection models (airway, gut) to prioritize physiologically relevant hits
- Co-supervise PhD students and contribute to method development, data management, and grant reporting
- Interest in working across the interface of imaging, microbiology, and drug discovery
- Support for independent fellowship applications (EMBO, HFSP, MSCA) where relevant Applicants should submit
- A cover letter (PDF, up to 2 pages) describing research interests, achievements and fit A CV with publication list Contact details for 3 referees Additional information Contract start date: negotiable
- Activity Rate : 100.00 Duration: 1 year, renewable
Notes et contenu original
- A postdoctoral position is available in the laboratory of Prof.
- Support for independent fellowship applications (EMBO, HFSP, MSCA) where relevant
- Informations
- Applicants should submit
- A cover letter (PDF, up to 2 pages) describing research interests, achievements and fit
- A CV with publication list
- Contact details for 3 referees
- Additional information
- Contract start date: negotiable
- Activity Rate : 100.00
Questions sur cette offre
Quel salaire propose EPFL pour ce poste ?
EPFL indique CHF 60 500 - 91 500 bruts par an pour ce poste à Lausanne. Il s'agit du salaire publié dans l'annonce d'origine (ou, si l'employeur ne précise pas de montant, d'une estimation réaliste pour le rôle et le secteur) — le calculateur de ce site le convertit en net réel une fois l'impôt frontalier et les cotisations sociales appliqués.
Est-ce un poste à temps plein, et quel type de contrat propose EPFL ?
Cette offre est un poste en temps plein. Le type de contrat affiché ici provient directement de l'annonce originale de l'employeur ; confirmez toujours les horaires exacts, le préavis et la durée d'essai avec EPFL pendant le processus de candidature, ces détails pouvant varier même au sein de la même catégorie de contrat.
Ai-je besoin d'un permis de frontalier pour un poste dans le canton de Vaud ?
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