Principal Scientist si-RNA Design — Roche
NouveauCHF 85 500 - 129 500
Roche · Basel (BS)
- Lieu
- Basel
- Contrat
- full-time
- Publié
- Hier
SalaireCHF 85 500 - 129 500
Vue d’ensemble du poste
At Roche you can show up as yourself, embraced for the unique qualities you bring.
Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally.
This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come.
- At Roche you can show up as yourself, embraced for the unique qualities you bring.
- Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally.
Processus de candidature
- AI Collaboration: Work in close partnership with our AI Experts to develop, validate, and apply the suit of AI design solutions.
Entreprise et contexte
- In Roche’s Pharmaceutical Research and Early Development organization (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs.
- At pRED, we are united by our mission to transform science into medicines.
- Together, we create a culture defined by curiosity, responsibility, and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.
- Therapeutic Modalities (TMo) organization, accountable for translating disease biology into high-quality drug candidates across small molecules, large molecules, oligonucleotides, and genomic medicines.
- By integrating deep modality expertise with cross-disciplinary collaboration, TMo drives innovation within and across platforms to enable differentiated, sustainable therapeutic impact.
- As the siRNA Design Principal Scientist, you will play a key role in designing and optimizing therapeutic siRNA against various disease targets working from Target Assessment through Lead Optimization across different disease areas.
- You will integrate deep scientific expertise with high quality execution of discovery programs. The Opportunity
- Therapeutic Design Strategy: Lead the drug design strategy of oligonucleotides with a strong focus on siRNAs, leveraging computational and empirical approaches, for both initial Proof of Concept on novel targets and full-scale lead optimization for clinical development.
- Guide projects holistically ensuring early design decisions align with late-stage clinical and manufacturing requirements.
- Utilize and invent new advanced chemical modification patterns and sequence selection strategies to optimize relevant pharmacological properties of siRNAs
Détails supplémentaires
- Join Roche, where every voice matters.
- You will integrate deep scientific expertise with high quality execution of discovery programs.
- Cross-Functional Alignment: Act as the RNAi subject matter expert in collaboration with project teams and disease experts.
- Familiarity with the interface of biology and data science; comfortable discussing parameters and data features with AI engineers; hands-on experience with command-line utilities and scripting languages for biological sequence analysis and data management.
- If you’re ready to make a meaningful impact on patients and healthcare systems worldwide, this is the place for you. A healthier future drives us to innovate.
Notes et contenu original
- The Position
- The Opportunity
- Who You Are
- If you’re ready to make a meaningful impact on patients and healthcare systems worldwide, this is the place for you.
- Who we are
- A healthier future drives us to innovate.
