Bioinformatician – Single-Cell Omics in Vascular & Skeletal Muscle Biology — ETH Zürich
- Location
- Zurich
- Contract
- fixed-term
- Posted
- Yesterday
Role overview
Bioinformatician – Single-Cell Omics in Vascular & Skeletal Muscle Biology
100%, Zurich, fixed-term print Drucken
The Laboratory of Exercise and Health, headed by Prof.
- Bioinformatician – Single-Cell Omics in Vascular & Skeletal Muscle Biology
- 100%, Zurich, fixed-term print Drucken
- Specific responsibilities include:
- Design, execute, and interpret scRNAseq analyses of human (patient-derived) and mouse skeletal muscle samples, identifying and annotating cell (sub)populations.
Main responsibilities
- Specific responsibilities include:
- Design, execute, and interpret scRNAseq analyses of human (patient-derived) and mouse skeletal muscle samples, identifying and annotating cell (sub)populations.
- Discuss and design follow-up wet lab experiments with colleagues.
- Integrate scRNAseq datasets with other omics information, including spatial transcriptomics, ATAC sequencing, metabolomics and/or multiplex imaging data.
- Perform cross-species (human–mouse) data integration to identify conserved and divergent cellular and molecular signatures of PAD.
Application process
- and further develop computational tools for cell-cell communication analysis (ligand-receptor interactions and signaling pathways) and constraint based metabolic modeling tools (e.g.
- COMPASS, scFEA) to link transcriptional states to cell metabolism.
- Analyze single-cell datasets generated from in vivo cell-cell interaction tracing models.
- Perform pseudobulk and differential expression analyses (e.g. edgeR) of scRNAseq/5’ECCITE-seq data from CRISPR perturbation screens.
- in silico perturbation approaches to nominate candidate regulators of cellular crosstalk for downstream functional validation.
- Build, document, and maintain reproducible bioinformatics pipelines, and support other lab members with transcriptomics and genomics data.
- Designing Shiny apps for data visualization for internal and possibly external use in publications.
- Contribute to manuscript preparation, data visualization, and project reporting, and stay current with emerging single-cell and spatial genomics methods. Profile
Additional details
- 100%, Zurich, fixed-term
- Katrien De Bock at the Department of Health Sciences and Technology (D-HEST), ETH Zurich, is offering a fixed-term position for a bioinformatician (postdoctoral level) to lead the single-cell and spatial transcriptomics analyses within the laboratory of Exercise and Health. Project background
- For more information on the lab, visit www.musec.ethz.ch
- Apply and further develop computational tools for cell-cell communication analysis (ligand-receptor interactions and signaling pathways) and constraint based metabolic modeling tools (e.g.
- Apply in silico perturbation approaches to nominate candidate regulators of cellular crosstalk for downstream functional validation.
- Contribute to manuscript preparation, data visualization, and project reporting, and stay current with emerging single-cell and spatial genomics methods.
- A strong interest in skeletal muscle physiology and/or vascular biology; prior research exposure to these fields is a plus but not required. Good understanding of b
Notes and original content
- Katrien De Bock at the Department of Health Sciences and Technology (D-HEST), ETH Zurich, is offering a fixed-term position for a bioinformatician (postdoctoral level) to lead the single-cell and spatial transcriptomics analyses within the laboratory of Exercise and Health.
- Project background
- Job description
- A strong interest in skeletal muscle physiology and/or vascular biology; prior research exposure to these fields is a plus but not required.
- Good understanding of b
Questions about this listing
What salary does ETH Zürich offer for this role?
ETH Zürich lists CHF 73'500 - 111'500 gross per year for this position in Zurich. This is the salary published in the original listing (or, when the employer omits a figure, a realistic estimate for the role and sector) — the calculator on this site converts it to your actual net take-home once cross-border tax and social contributions are applied.
Is this a full-time role, and what type of contract does ETH Zürich offer?
This listing is a fixed-term contract position. The contract type shown here comes directly from the employer's original posting; always confirm exact hours, notice period and probation length with ETH Zürich during the application process, since these details can vary by role even within the same contract category.
Do I need a cross-border work permit for a role in Zürich?
EU/EFTA residents living in the border zone of the country adjoining Canton Zürich can apply for a G permit; the Swiss employer files it with that canton's migration office after the contract is signed. Border-zone rules and processing times vary by neighbouring country and canton, so confirm the specifics with Zürich's cantonal migration office or with HR during the application.
How do I apply for this position at ETH Zürich?
Use the "Apply now" button on this page — it links directly to ETH Zürich's original listing at jobs.ethz.ch, so your application goes straight to the employer's own applicant-tracking system. Frontaliere Ticino does not collect or forward applications itself.
