Postdoctoral Researcher — Idorsia Pharmaceuticals
- Location
- Basel
- Contract
- full-time
- Posted
- Yesterday
Role overview
About the Company
The purpose of Idorsia is to discover, develop, and commercialize innovative medicines to help more patients.
Headquartered in Switzerland – a biotech-hub of Europe – Idorsia is a high-potential biopharmaceutical company, specialized in the discovery, development and commercialization of innovative small molecules, with the aim of transforming the horizon of therapeutic options.
- About the Company
- The purpose of Idorsia is to discover, develop, and commercialize innovative medicines to help more patients.
- Job Responsibilities
- Establish and evaluate New Approach Methodologies (NAMs) such as advanced in vitro hepatic systems to improve the prediction of human clearance, with a particular focus on low-turnover compounds.
Main responsibilities
- Job Responsibilities
- Establish and evaluate New Approach Methodologies (NAMs) such as advanced in vitro hepatic systems to improve the prediction of human clearance, with a particular focus on low-turnover compounds.
- Compare intrinsic clearance data generated in conventional systems, such as human liver microsomes and cryopreserved hepatocytes, with data from more complex liver-cell models such as HepaRG, HepatoPac, TruVivo or related systems.
- Investigate the impact of nonspecific binding, compound stability, incubation recovery and free concentration on the interpretation of clearance data and support in vitro–in vivo extrapolation in collaboration with DMPK modelers.
- Assess the suitability of advanced hepatic systems for drug-metabolizing enzyme phenotyping in comparison with human liver microsomes, integrating metabolite identification where appropriate.
- Document, analyze and present experimental results in multidisciplinary project teams, and contribute to scientific reports, internal presentations, conference communications and peer-reviewed publications. Candidate’s Requirements
- PhD in pharmaceutical sciences, analytical chemistry, biochemistry, biology, pharmacology or a related discipline, with solid scientific training and a strong interest in applying experimental and analytical skills to DMPK questions.
- Hands-on experience with cell culture and LC-MS/MS bioanalysis is required; experience with high-resolution MS and/or metabolite identification is an advantage.
- Experience with in vitro ADME/DMPK assays, such as microsomal or hepatocyte stability, protein binding, drug-metabolizing enzyme phenotyping, is desirable.
- Good understanding of drug metabolism, hepatic clearance mechanisms, enzyme phenotyping and in vitro–in vivo extrapolation, or strong motivation to develop expertise in these areas.
Application process
- Develop and apply robust LC-MS/MS bioanalytical methods to quantify parent compound depletion and, where appropriate, metabolite formation in those assays.
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Contacts
- For those partners who have no valid, signed Master Service Agreement in place with Idorsia, please note that all unsolicited resumes, CVs, anonymous profiles, or any other candidate details submitted through our website or to personal e-mail accounts of employees of Idorsia Pharmaceuticals (including any of its subsidiaries, affiliates or related companies) are considered the property of Idorsia Pharmaceuticals and are not subject to payment of any form of introduction, placement or referral fees.
Company and context
- Proactive, collaborative and reliable personality with strong analytical thinking, excellent organizational and communication skills, and the ability to work effectively in a multidisciplinary and multicultural environment.
- Excellent knowledge of English. Work Location: Allschwil – Basel Area Country: Switzerland Business Area: Non Clinical Development Schedule: Fulltime Job Type: Postdoc Programme
- 2 years Job ID: 4809
- At Idorsia, we harness the power of difference, authenticity and inclusion to achieve business success.
- We are committed to fostering respect, fairness and equal opportunities for all job applicants and all our employees.
- All qualified applicants will receive consideration for employment without regard to race, color, religion, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against based on disability.
- Please be informed that if you are selected for this position, your employment will be subject to a pre-employment background screening process, of which you will be informed in greater detail in due course.
- Idorsia operates a strictly controlled list of preferred recruitment partners.
Additional details
- Document, analyze and present experimental results in multidisciplinary project teams, and contribute to scientific reports, internal presentations, conference communications and peer-reviewed publications. Candidate’s Requirements
- Excellent knowledge of English. Work Location: Allschwil – Basel Area Country: Switzerland Business Area: Non Clinical Development Job Type: Postdoc Programme Corporate Functions
Notes and original content
- Document, analyze and present experimental results in multidisciplinary project teams, and contribute to scientific reports, internal presentations, conference communications and peer-reviewed publications.
- Candidate’s Requirements
- Excellent knowledge of English.
- Work Location: Allschwil – Basel Area
- Country: Switzerland
- Business Area: Non Clinical Development
- Schedule: Fulltime
- Job Type: Postdoc Programme
- Job ID: 4809
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Questions about this listing
What salary does Idorsia Pharmaceuticals offer for this role?
Idorsia Pharmaceuticals lists CHF 62'000 - 94'000 gross per year for this position in Basel. This is the salary published in the original listing (or, when the employer omits a figure, a realistic estimate for the role and sector) — the calculator on this site converts it to your actual net take-home once cross-border tax and social contributions are applied.
Is this a full-time role, and what type of contract does Idorsia Pharmaceuticals offer?
This listing is a full-time position. The contract type shown here comes directly from the employer's original posting; always confirm exact hours, notice period and probation length with Idorsia Pharmaceuticals during the application process, since these details can vary by role even within the same contract category.
Do I need a cross-border work permit for a role in Basel?
EU/EFTA residents living in the border zone of the country adjoining Canton Basel can apply for a G permit; the Swiss employer files it with that canton's migration office after the contract is signed. Border-zone rules and processing times vary by neighbouring country and canton, so confirm the specifics with Basel's cantonal migration office or with HR during the application.
How do I apply for this position at Idorsia Pharmaceuticals?
Use the "Apply now" button on this page — it links directly to Idorsia Pharmaceuticals's original listing at careers.idorsia.com, so your application goes straight to the employer's own applicant-tracking system. Frontaliere Ticino does not collect or forward applications itself.
