Postdoctoral Researcher — Idorsia Pharmaceuticals
- Ort
- Basel
- Vertrag
- full-time
- Veröffentlicht
- Gestern
Rollenüberblick
About the Company
The purpose of Idorsia is to discover, develop, and commercialize innovative medicines to help more patients.
Headquartered in Switzerland – a biotech-hub of Europe – Idorsia is a high-potential biopharmaceutical company, specialized in the discovery, development and commercialization of innovative small molecules, with the aim of transforming the horizon of therapeutic options.
- About the Company
- The purpose of Idorsia is to discover, develop, and commercialize innovative medicines to help more patients.
- Job Responsibilities
- Establish and evaluate New Approach Methodologies (NAMs) such as advanced in vitro hepatic systems to improve the prediction of human clearance, with a particular focus on low-turnover compounds.
Hauptaufgaben
- Job Responsibilities
- Establish and evaluate New Approach Methodologies (NAMs) such as advanced in vitro hepatic systems to improve the prediction of human clearance, with a particular focus on low-turnover compounds.
- Compare intrinsic clearance data generated in conventional systems, such as human liver microsomes and cryopreserved hepatocytes, with data from more complex liver-cell models such as HepaRG, HepatoPac, TruVivo or related systems.
- Investigate the impact of nonspecific binding, compound stability, incubation recovery and free concentration on the interpretation of clearance data and support in vitro–in vivo extrapolation in collaboration with DMPK modelers.
- Assess the suitability of advanced hepatic systems for drug-metabolizing enzyme phenotyping in comparison with human liver microsomes, integrating metabolite identification where appropriate.
- Document, analyze and present experimental results in multidisciplinary project teams, and contribute to scientific reports, internal presentations, conference communications and peer-reviewed publications. Candidate’s Requirements
- PhD in pharmaceutical sciences, analytical chemistry, biochemistry, biology, pharmacology or a related discipline, with solid scientific training and a strong interest in applying experimental and analytical skills to DMPK questions.
- Hands-on experience with cell culture and LC-MS/MS bioanalysis is required; experience with high-resolution MS and/or metabolite identification is an advantage.
- Experience with in vitro ADME/DMPK assays, such as microsomal or hepatocyte stability, protein binding, drug-metabolizing enzyme phenotyping, is desirable.
- Good understanding of drug metabolism, hepatic clearance mechanisms, enzyme phenotyping and in vitro–in vivo extrapolation, or strong motivation to develop expertise in these areas.
Bewerbungsprozess
- Develop and apply robust LC-MS/MS bioanalytical methods to quantify parent compound depletion and, where appropriate, metabolite formation in those assays.
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Kontakte
- For those partners who have no valid, signed Master Service Agreement in place with Idorsia, please note that all unsolicited resumes, CVs, anonymous profiles, or any other candidate details submitted through our website or to personal e-mail accounts of employees of Idorsia Pharmaceuticals (including any of its subsidiaries, affiliates or related companies) are considered the property of Idorsia Pharmaceuticals and are not subject to payment of any form of introduction, placement or referral fees.
Unternehmen und Kontext
- Proactive, collaborative and reliable personality with strong analytical thinking, excellent organizational and communication skills, and the ability to work effectively in a multidisciplinary and multicultural environment.
- Excellent knowledge of English. Work Location: Allschwil – Basel Area Country: Switzerland Business Area: Non Clinical Development Schedule: Fulltime Job Type: Postdoc Programme
- 2 years Job ID: 4809
- At Idorsia, we harness the power of difference, authenticity and inclusion to achieve business success.
- We are committed to fostering respect, fairness and equal opportunities for all job applicants and all our employees.
- All qualified applicants will receive consideration for employment without regard to race, color, religion, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against based on disability.
- Please be informed that if you are selected for this position, your employment will be subject to a pre-employment background screening process, of which you will be informed in greater detail in due course.
- Idorsia operates a strictly controlled list of preferred recruitment partners.
Weitere Details
- Document, analyze and present experimental results in multidisciplinary project teams, and contribute to scientific reports, internal presentations, conference communications and peer-reviewed publications. Candidate’s Requirements
- Excellent knowledge of English. Work Location: Allschwil – Basel Area Country: Switzerland Business Area: Non Clinical Development Job Type: Postdoc Programme Corporate Functions
Notizen und Originalinhalt
- Document, analyze and present experimental results in multidisciplinary project teams, and contribute to scientific reports, internal presentations, conference communications and peer-reviewed publications.
- Candidate’s Requirements
- Excellent knowledge of English.
- Work Location: Allschwil – Basel Area
- Country: Switzerland
- Business Area: Non Clinical Development
- Schedule: Fulltime
- Job Type: Postdoc Programme
- Job ID: 4809
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Fragen zu dieser Stellenanzeige
Welches Gehalt bietet Idorsia Pharmaceuticals für diese Stelle?
Idorsia Pharmaceuticals gibt CHF 62'000 - 94'000 brutto pro Jahr für diese Position in Basel an. Dies ist das im Original-Inserat veröffentlichte Gehalt (oder, falls der Arbeitgeber keinen Betrag nennt, eine realistische Schätzung für Rolle und Branche) — der Rechner auf dieser Seite berechnet daraus Ihr tatsächliches Netto nach Grenzgänger-Steuer und Sozialabgaben.
Ist das eine Vollzeitstelle, und welchen Vertragstyp bietet Idorsia Pharmaceuticals?
Diese Stelle ist eine Vollzeit-Position. Der hier angezeigte Vertragstyp stammt direkt aus dem Original-Inserat des Arbeitgebers; klären Sie genaue Arbeitszeiten, Kündigungsfrist und Probezeit während des Bewerbungsprozesses mit Idorsia Pharmaceuticals, da diese Details auch innerhalb derselben Vertragskategorie variieren können.
Brauche ich eine Grenzgänger-Bewilligung für eine Stelle im Kanton Basel?
EU/EFTA-Bürger mit Wohnsitz in der Grenzzone des an den Kanton Basel angrenzenden Landes können eine G-Bewilligung beantragen; der Schweizer Arbeitgeber reicht sie nach Vertragsunterzeichnung beim Migrationsamt dieses Kantons ein. Grenzzonen-Regeln und Bearbeitungszeiten variieren je nach Nachbarland und Kanton — klären Sie die Details mit dem Migrationsamt des Kantons Basel oder mit HR während der Bewerbung.
Wie bewerbe ich mich für diese Stelle bei Idorsia Pharmaceuticals?
Nutzen Sie die Schaltfläche "Jetzt bewerben" auf dieser Seite — sie führt direkt zum Original-Inserat von Idorsia Pharmaceuticals unter careers.idorsia.com, sodass Ihre Bewerbung direkt im Bewerbermanagementsystem des Arbeitgebers landet. Frontaliere Ticino sammelt oder leitet keine Bewerbungen selbst weiter.
