Postdoctoral Researcher — Idorsia Pharmaceuticals
- Lieu
- Basel
- Contrat
- full-time
- Publié
- Hier
Vue d’ensemble du poste
About the Company
The purpose of Idorsia is to discover, develop, and commercialize innovative medicines to help more patients.
Headquartered in Switzerland – a biotech-hub of Europe – Idorsia is a high-potential biopharmaceutical company, specialized in the discovery, development and commercialization of innovative small molecules, with the aim of transforming the horizon of therapeutic options.
- About the Company
- The purpose of Idorsia is to discover, develop, and commercialize innovative medicines to help more patients.
- Job Responsibilities
- Establish and evaluate New Approach Methodologies (NAMs) such as advanced in vitro hepatic systems to improve the prediction of human clearance, with a particular focus on low-turnover compounds.
Responsabilités principales
- Job Responsibilities
- Establish and evaluate New Approach Methodologies (NAMs) such as advanced in vitro hepatic systems to improve the prediction of human clearance, with a particular focus on low-turnover compounds.
- Compare intrinsic clearance data generated in conventional systems, such as human liver microsomes and cryopreserved hepatocytes, with data from more complex liver-cell models such as HepaRG, HepatoPac, TruVivo or related systems.
- Investigate the impact of nonspecific binding, compound stability, incubation recovery and free concentration on the interpretation of clearance data and support in vitro–in vivo extrapolation in collaboration with DMPK modelers.
- Assess the suitability of advanced hepatic systems for drug-metabolizing enzyme phenotyping in comparison with human liver microsomes, integrating metabolite identification where appropriate.
- Document, analyze and present experimental results in multidisciplinary project teams, and contribute to scientific reports, internal presentations, conference communications and peer-reviewed publications. Candidate’s Requirements
- PhD in pharmaceutical sciences, analytical chemistry, biochemistry, biology, pharmacology or a related discipline, with solid scientific training and a strong interest in applying experimental and analytical skills to DMPK questions.
- Hands-on experience with cell culture and LC-MS/MS bioanalysis is required; experience with high-resolution MS and/or metabolite identification is an advantage.
- Experience with in vitro ADME/DMPK assays, such as microsomal or hepatocyte stability, protein binding, drug-metabolizing enzyme phenotyping, is desirable.
- Good understanding of drug metabolism, hepatic clearance mechanisms, enzyme phenotyping and in vitro–in vivo extrapolation, or strong motivation to develop expertise in these areas.
Processus de candidature
- Develop and apply robust LC-MS/MS bioanalytical methods to quantify parent compound depletion and, where appropriate, metabolite formation in those assays.
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Contacts
- For those partners who have no valid, signed Master Service Agreement in place with Idorsia, please note that all unsolicited resumes, CVs, anonymous profiles, or any other candidate details submitted through our website or to personal e-mail accounts of employees of Idorsia Pharmaceuticals (including any of its subsidiaries, affiliates or related companies) are considered the property of Idorsia Pharmaceuticals and are not subject to payment of any form of introduction, placement or referral fees.
Entreprise et contexte
- Proactive, collaborative and reliable personality with strong analytical thinking, excellent organizational and communication skills, and the ability to work effectively in a multidisciplinary and multicultural environment.
- Excellent knowledge of English. Work Location: Allschwil – Basel Area Country: Switzerland Business Area: Non Clinical Development Schedule: Fulltime Job Type: Postdoc Programme
- 2 years Job ID: 4809
- At Idorsia, we harness the power of difference, authenticity and inclusion to achieve business success.
- We are committed to fostering respect, fairness and equal opportunities for all job applicants and all our employees.
- All qualified applicants will receive consideration for employment without regard to race, color, religion, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against based on disability.
- Please be informed that if you are selected for this position, your employment will be subject to a pre-employment background screening process, of which you will be informed in greater detail in due course.
- Idorsia operates a strictly controlled list of preferred recruitment partners.
Détails supplémentaires
- Document, analyze and present experimental results in multidisciplinary project teams, and contribute to scientific reports, internal presentations, conference communications and peer-reviewed publications. Candidate’s Requirements
- Excellent knowledge of English. Work Location: Allschwil – Basel Area Country: Switzerland Business Area: Non Clinical Development Job Type: Postdoc Programme Corporate Functions
Notes et contenu original
- Document, analyze and present experimental results in multidisciplinary project teams, and contribute to scientific reports, internal presentations, conference communications and peer-reviewed publications.
- Candidate’s Requirements
- Excellent knowledge of English.
- Work Location: Allschwil – Basel Area
- Country: Switzerland
- Business Area: Non Clinical Development
- Schedule: Fulltime
- Job Type: Postdoc Programme
- Job ID: 4809
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Questions sur cette offre
Quel salaire propose Idorsia Pharmaceuticals pour ce poste ?
Idorsia Pharmaceuticals indique CHF 62 000 - 94 000 bruts par an pour ce poste à Basel. Il s'agit du salaire publié dans l'annonce d'origine (ou, si l'employeur ne précise pas de montant, d'une estimation réaliste pour le rôle et le secteur) — le calculateur de ce site le convertit en net réel une fois l'impôt frontalier et les cotisations sociales appliqués.
Est-ce un poste à temps plein, et quel type de contrat propose Idorsia Pharmaceuticals ?
Cette offre est un poste en temps plein. Le type de contrat affiché ici provient directement de l'annonce originale de l'employeur ; confirmez toujours les horaires exacts, le préavis et la durée d'essai avec Idorsia Pharmaceuticals pendant le processus de candidature, ces détails pouvant varier même au sein de la même catégorie de contrat.
Ai-je besoin d'un permis de frontalier pour un poste dans le canton de Bâle ?
Les résidents UE/AELE domiciliés dans la zone frontalière du pays voisin du canton de Bâle peuvent demander un permis G ; l'employeur suisse le dépose auprès de l'office cantonal des migrations après signature du contrat. Les règles de zone frontalière et les délais varient selon le pays voisin et le canton — confirmez les détails auprès de l'office des migrations du canton de Bâle ou avec les RH pendant la candidature.
Comment postuler à ce poste chez Idorsia Pharmaceuticals ?
Utilisez le bouton « Postuler maintenant » sur cette page — il renvoie directement à l'annonce originale de Idorsia Pharmaceuticals sur careers.idorsia.com, votre candidature arrive donc directement dans le système de suivi des candidatures de l'employeur. Frontaliere Ticino ne collecte ni ne transmet lui-même les candidatures.
