Principal Scientist - Mid/Large Scale Oligonucleotide Synthesis, xRNA Therapeutics — Novartis
- Location
- Basel
- Contract
- full-time
- Posted
- Yesterday
Role overview
Salary Range
CHF93,800.00
CHF174,200.00 Job Description Summary LI-Onsite Location: Basel, Switzerland Role Purpose:
- Salary Range:
- CHF93,800.00
- Key Responsibilities
- Plan and execute medium- and large-scale solid-phase synthesis, purification, and analysis of chemically modified oligonucleotides (siRNAs, ASOs, and other emerging synthetic modalities) and conjugates to support our xRNA therapeutics portfolio.
- and Requirements:
- Ph.D. in Chemistry or related disciplines with a strong focus on oligonucleotide chemistry and synthesis.
Main responsibilities
- Key Responsibilities
- Plan and execute medium- and large-scale solid-phase synthesis, purification, and analysis of chemically modified oligonucleotides (siRNAs, ASOs, and other emerging synthetic modalities) and conjugates to support our xRNA therapeutics portfolio.
- Mentor and lead a team of scientists specialized in oligonucleotide synthesis, purification, analysis, and conjugation at millimole scale.
- Collaborate with global discovery, development, and project teams to advance novel oligonucleotide chemistries and facilitate their successful transition from research into development.
- Identify and implement innovative technologies, workflows, and manufacturing approaches to enhance operational excellence, production capabilities, and turnaround times of siRNA, ASO and other oligonucleotide modalities supporting in vivo and preclinical studies.
Key requirements
- and Requirements:
- Ph.D. in Chemistry or related disciplines with a strong focus on oligonucleotide chemistry and synthesis.
- Minimum 2–3 years of industry experience and proven expertise in mid- large-scale oligonucleotide solid phase synthesis, purification, analysis, conjugation, and other related processes.
- Extensive experience operating and maintenance of AKTA Oligopilot/Oligosynt systems and AKTA Avant purification platforms, with strong proficiency in Unicorn software.
- Strong hands-on experience with process development, method optimization and scale-up strategies of oligonucleotides.
- Demonstrated leadership experience, including mentoring, and team management.
- Strong communication skills and ability to work effectively in a matrixed cross-functional global teams’ environment.
What the company offers
- & Rewards
- At Novartis, we’re committed to reimagining medicine together - and rewarding the people who make it happen.
- Expected Annual Base Salary Range for role: 93,800.00
- 174,200.00 CHF Annual
- The base salary offered is determined based on gender-neutral objectives, such as relevant skills, competencies and experience in accordance with the Novartis pay setting policy and upon joining Novartis will be reviewed periodically.
- In addition to your base salary, you may be eligible for a performance-based bonus depending on certain performance parameters.
- The rewards of being part of our team go far beyond base pay and incentives.
- We also offer a variety of competitive benefits in kind to help you thrive personally and professionally, such as insurance plans, retirement plans, wellbeing resources and global recognition programs.
- In addition, we provide flexible and hybrid working options, where possible, and minimum 14 weeks paid parental leave.
- Pay equity is a fundamental principle of our employment policy and reflects our commitment to create a diverse, equitable and inclusive environment that treats all employees with dignity and respect, as outlined in our Code of Ethics. Read our broch
Application process
- Communicate scientific findings and project updates effectively to internal and external stakeholders through presentations, technical reports, and patent applications.
- Maintain high-quality scientific documentation, including electronic laboratory notebooks (ELNs), experimental protocols, technical reports, and project summaries.
- Foster a culture of scientific excellence, collaboration, continuous learning, and solution-oriented problem solving.
Additional details
- Job Description Summary Location: Basel, Switzerland
- This role requires extensive collaboration within a multidisciplinary environment, bridging research and development to enable the discovery and advancement of innovative RNA therapies that address significant unmet medical needs. Qualifications and Requirements:
- Pay equity is a fundamental principle of our employment policy and reflects our commitment to create a diverse, equitable and inclusive environment that treats all employees with dignity and respect, as outlined in our Code of Ethics.
Notes and original content
- CHF174,200.00
- Job Description Summary
- Location: Basel, Switzerland
- Role Purpose:
- This role requires extensive collaboration within a multidisciplinary environment, bridging research and development to enable the discovery and advancement of innovative RNA therapies that address significant unmet medical needs.
- Job Description
- Qualifications and Requirements:
- Benefits & Rewards
- Read our broch
Questions about this listing
What salary does Novartis offer for this role?
Novartis lists CHF 85'500 - 129'500 gross per year for this position in Basel. This is the salary published in the original listing (or, when the employer omits a figure, a realistic estimate for the role and sector) — the calculator on this site converts it to your actual net take-home once cross-border tax and social contributions are applied.
Is this a full-time role, and what type of contract does Novartis offer?
This listing is a full-time position. The contract type shown here comes directly from the employer's original posting; always confirm exact hours, notice period and probation length with Novartis during the application process, since these details can vary by role even within the same contract category.
Do I need a cross-border work permit for a role in Basel?
EU/EFTA residents living in the border zone of the country adjoining Canton Basel can apply for a G permit; the Swiss employer files it with that canton's migration office after the contract is signed. Border-zone rules and processing times vary by neighbouring country and canton, so confirm the specifics with Basel's cantonal migration office or with HR during the application.
How do I apply for this position at Novartis?
Use the "Apply now" button on this page — it links directly to Novartis's original listing at novartis.wd3.myworkdayjobs.com, so your application goes straight to the employer's own applicant-tracking system. Frontaliere Ticino does not collect or forward applications itself.
