DMPK-PD Project Leader — Roche
- Location
- Basel
- Contract
- full-time
- Posted
- 40 days ago
Role overview
At Roche you can show up as yourself, embraced for the unique qualities you bring.
Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally.
This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come.
- At Roche you can show up as yourself, embraced for the unique qualities you bring.
- Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally.
- Your Impact & Responsibilities:
- Translational Expertise: Serve as the subject matter expert, guiding early discovery teams in developing translational strategies towards preclinical and clinical evaluation of target modulation, leveraging biochemical and pharmacological knowledge.
- Implementation & Innovation: Pioneer and oversee the implementation of robust biomarker and bioanalytical strategies in close partnership with key stakeholders to maximise patient safety and therapeutic benefit.
Main responsibilities
- Your Impact & Responsibilities:
- Translational Expertise: Serve as the subject matter expert, guiding early discovery teams in developing translational strategies towards preclinical and clinical evaluation of target modulation, leveraging biochemical and pharmacological knowledge.
What the company offers
- Implementation & Innovation: Pioneer and oversee the implementation of robust biomarker and bioanalytical strategies in close partnership with key stakeholders to maximise patient safety and therapeutic benefit.
Application process
- Strategic Leadership: Define and lead drug design teams towards required molecular properties; define comprehensive compound profiling strategies via application of cutting-edge DMPK principles with target biology validation and translational PK/PD concepts.
- Applies Modelling & Simulation (M&S): Direct machine learning (ML and AI), M&S activities (including PK/PD, PBPK, DDI, and human dose/regimen prediction) to critically inform and de-risk projects from Lead Optimisation (LO) through early and late-stage clinical development (EIH, Ph 2/3).
- Regulatory Mastery: Author and present definitive, high-quality scientific assessments of non-clinical DMPK data for critical internal program reviews and all major external regulatory submissions (IND, IB, CTA, NDA, BLA), ensuring global compliance and accelerated timelines.
- Cross-Functional Influence: Champion transparent, data-driven decision-making, acting as a trusted advisor and cultivating high-trust professional relationships across global project teams, governance bodies, and external partnerships. Who You Are
- You hold a PharmD or PhD in Pharmaceutical Sciences, Pharmacology, Bioengineering or similar, coupled with over 5
- 10 years of post-PhD industry experience in a pharmacokinetic-related role.
- You possess expertise across the entire discovery, preclinical and development spectrum, cove
Company and context
- In Roche’s Pharmaceutical Research and Early Development organization (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs.
- At pRED, we are united by our mission to transform science into medicines.
- Together, we create a culture defined by curiosity, responsibility, and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.
- At the intersection of science and innovation, pRED’s Pharmaceutical Sciences (PS) organisation enables the discovery and development of safe and effective therapeutics at optimal doses in relevant populations, with a vision to power translation, continuously improve the accuracy of our predictions and accelerate the development of tomorrow's medicines.
- By seamlessly integrating our three core pillars
- Translational Safety, Translational Pharmacology, and Biomarkers - we drive end-to-end asset development across the entire value chain, from target assessment to on-market support.
- Our mission is to continuously improve predictive accuracy, optimise dosing strategies for the right patient populations, and accelerate the development of tomorrow's safe and effective therapeutics. The Opportunity
- As an experienced DMPK-PD Project Leader within the Translational DMPK-PD Department, you will be pivotal in ensuring the right drug is delivered at the right dose, safely and efficaciously to patients.
- You will lead nonclinical and translational strategies, collaborate across therapeutic areas to transform scientific hypotheses into clinical ready drug candidates.
Additional details
- Join Roche, where every voice matters.
- Our mission is to continuously improve predictive accuracy, optimise dosing strategies for the right patient populations, and accelerate the development of tomorrow's safe and effective therapeutics.
- Cross-Functional Influence: Champion transparent, data-driven decision-making, acting as a trusted advisor and cultivating high-trust professional relationships across global project teams, governance bodies, and external partnerships.
Notes and original content
- The Position
- The Opportunity
- Who You Are
Questions about this listing
What salary does Roche offer for this role?
Roche lists CHF 62'000 - 94'000 gross per year for this position in Basel. This is the salary published in the original listing (or, when the employer omits a figure, a realistic estimate for the role and sector) — the calculator on this site converts it to your actual net take-home once cross-border tax and social contributions are applied.
Is this a full-time role, and what type of contract does Roche offer?
This listing is a full-time position. The contract type shown here comes directly from the employer's original posting; always confirm exact hours, notice period and probation length with Roche during the application process, since these details can vary by role even within the same contract category.
Do I need a cross-border work permit for a role in Basel?
EU/EFTA residents living in the border zone of the country adjoining Canton Basel can apply for a G permit; the Swiss employer files it with that canton's migration office after the contract is signed. Border-zone rules and processing times vary by neighbouring country and canton, so confirm the specifics with Basel's cantonal migration office or with HR during the application.
How do I apply for this position at Roche?
Use the "Apply now" button on this page — it links directly to Roche's original listing at roche.wd3.myworkdayjobs.com, so your application goes straight to the employer's own applicant-tracking system. Frontaliere Ticino does not collect or forward applications itself.
