Senior Principal Scientist/Associate Director Clinical PBPK (Dual Level Posting) — Novartis
- Location
- Basel
- Contract
- full-time
- Posted
- Yesterday
Role overview
Salary Range
CHF122,500.00
CHF227,500.00 Job Description Summary LI-Hybrid
- Salary Range:
- CHF122,500.00
- The candidate’s core responsibilities will include PBPK modeling to integrate in vitro and in vivo data for drug-drug interaction (DDI) assessments, impact of biopharmaceutics properties on absorption, and pharmacokinetic (PK) predictions in humans as well as in specific populations (e.g. disease, organ impairment, pediatrics).
- The ultimate goal of this work is to be on the forefront of applying PBPK models to inform the safe administration of our drug candidates in the clinic, to optimize clinical trial designs, and waive clinical trials, ultimately, to get our medicines to patients faster.
- & Rewards
- At Novartis, we’re committed to reimagining medicine together - and rewarding the people who make it happen.
Main responsibilities
- The candidate’s core responsibilities will include PBPK modeling to integrate in vitro and in vivo data for drug-drug interaction (DDI) assessments, impact of biopharmaceutics properties on absorption, and pharmacokinetic (PK) predictions in humans as well as in specific populations (e.g. disease, organ impairment, pediatrics).
- The ultimate goal of this work is to be on the forefront of applying PBPK models to inform the safe administration of our drug candidates in the clinic, to optimize clinical trial designs, and waive clinical trials, ultimately, to get our medicines to patients faster.
- The role requires a deep understanding of ADME/DMPK principles and biopharmaceutics knowledge, experience with industry standard PBPK modeling packages (such as GastroPlus or Simcyp) or bespoke PBPK models, regulatory submissions involving PBPK modeling, interdisciplinary thinking and great attention to detail.
- Expert PBPK modeler to provide translational modeling support for global drug discovery and development projects
- Integrate PK/ PD data, ADME and DDI findings
- Ability to interpret and communicate modeling results and potential impact to project teams
- Prepare summary documents for use in regulatory submissions and ability to respond independently to health authority questions Essential requirements
- PhD in pharmaceutical sciences or related discipline with experience in ADME/DMPK sciences, biopharmaceutics, and modeling and simulation.
- At least 5+ years in pharmaceutical industry including demonstrated knowledge and experience with PBPK modeling.
- The level of the position would depend upon the experience of the candidate.
What the company offers
- & Rewards
- At Novartis, we’re committed to reimagining medicine together - and rewarding the people who make it happen.
- Expected Annual Base Salary Range for role:
Application process
- The Modeling & Simulation group within PK Sciences is looking for a Principal Scientist to Associate Director level modeler, to develop and apply translational physiologically based pharmacokinetic (PBPK) modeling along with data analysis techniques to facilitate drug discovery, development, and translational research across disease areas.
- The applicant will work in a dynamic and multidisciplinary environment to build, verify and apply quality translational/biopharmaceutical PBPK models. Job Description Key responsibilities:
- Perform translational PBPK analyses to predict clinical drug exposure in specific populations, assess potential for DDI, understand clinical impact of disease on drug exposure, as well as apply biopharmaceutic PBPK modeling to support formulation changes and achieve clinical biowaivers
Additional details
- Job Description Summary
- Internal Title: Senior Principal Scientist or Associate Director Location: Basel, Switzerland
- The applicant will work in a dynamic and multidisciplinary environment to build, verify and apply quality translational/biopharmaceutical PBPK models. Key responsibilities:
- Prepare summary documents for use in regulatory submissions and ability to respond independently to health authority questions Essential requirements
Notes and original content
- CHF227,500.00
- Internal Title: Senior Principal Scientist or Associate Director
- Location: Basel, Switzerland
- The applicant will work in a dynamic and multidisciplinary environment to build, verify and apply quality translational/biopharmaceutical PBPK models.
- Job Description
- Key responsibilities:
- Prepare summary documents for use in regulatory submissions and ability to respond independently to health authority questions
- Essential requirements
- Benefits & Rewards
Questions about this listing
What salary does Novartis offer for this role?
Novartis lists CHF 85'500 - 129'500 gross per year for this position in Basel. This is the salary published in the original listing (or, when the employer omits a figure, a realistic estimate for the role and sector) — the calculator on this site converts it to your actual net take-home once cross-border tax and social contributions are applied.
Is this a full-time role, and what type of contract does Novartis offer?
This listing is a full-time position. The contract type shown here comes directly from the employer's original posting; always confirm exact hours, notice period and probation length with Novartis during the application process, since these details can vary by role even within the same contract category.
Do I need a cross-border work permit for a role in Basel?
EU/EFTA residents living in the border zone of the country adjoining Canton Basel can apply for a G permit; the Swiss employer files it with that canton's migration office after the contract is signed. Border-zone rules and processing times vary by neighbouring country and canton, so confirm the specifics with Basel's cantonal migration office or with HR during the application.
How do I apply for this position at Novartis?
Use the "Apply now" button on this page — it links directly to Novartis's original listing at novartis.wd3.myworkdayjobs.com, so your application goes straight to the employer's own applicant-tracking system. Frontaliere Ticino does not collect or forward applications itself.
