Post Doctorate Scientist (IHB) - In Vitro Modeling Adaptive Immunologist — Roche
NewCHF 49'500 - 75'000
Roche · Basel (BS)
- Location
- Basel
- Contract
- full-time
- Posted
- 2 days ago
SalaryCHF 49'500 - 75'000
Role overview
At Roche you can show up as yourself, embraced for the unique qualities you bring.
Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally.
This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come.
- At Roche you can show up as yourself, embraced for the unique qualities you bring.
- Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally.
Company and context
- Develop and implement in vitro model systems that recapitulate key features of CNS meningeal inflammation, including immune–stromal interactions and TLS-like organization, and model disease-relevant immune responses in contexts such as multiple sclerosis (MS) and Alzheimer’s disease (AD).
- Perform deep immune phenotyping and generate multi-omic datasets (e.g., flow cytometry, single-cell RNA-seq, V(D)J profiling) to characterize immune–stromal interactions, define adaptive immune cell states, and functionally validate and refine in vitro models aligned with human atlases and translational goals. Scientific Growth & Translation:
- Partner closely with computational scientists to translate atlas-derived cell states into experimentally testable hypotheses and iteratively refine in vitro models based on human data.
- Engage with teams across IHB and pRED—including direct exposure to drug developers—to align experimental findings with translational questions in Neuroscience and Rare Diseases and contribute to long-term portfolio impact.
- Communicate findings through scientific manuscripts, presentations, and cross-functional discussions, clearly articulating experimental insights and their relevance to human biology and therapeutic strategy.
- Who You Are You are a hands-on experimental scientist with a strong foundation in immunology and a deep interest in human disease biology.
- You enjoy working collaboratively with computational scientists and are motivated by the opportunity to generate data that directly informs systems-level understanding.
- You are excited not only by profiling human immune responses, but also by building experimental systems that capture key features of tissue-specific immunity, including meningeal inflammation and ectopic lymphoid structure-like biology. Furthermore, You bring: A Ph.D. in Immunol
Additional details
- Perform deep immune phenotyping and generate multi-omic datasets (e.g., flow cytometry, single-cell RNA-seq, V(D)J profiling) to characterize immune–stromal interactions, define adaptive immune cell states, and functionally validate and refine in vitro models aligned with human atlases and translational goals. Scientific Growth & Translation:
- You are excited not only by profiling human immune responses, but also by building experimental systems that capture key features of tissue-specific immunity, including meningeal inflammation and ectopic lymphoid structure-like biology. Furthermore, You bring:
Notes and original content
- Perform deep immune phenotyping and generate multi-omic datasets (e.g., flow cytometry, single-cell RNA-seq, V(D)J profiling) to characterize immune–stromal interactions, define adaptive immune cell states, and functionally validate and refine in vitro models aligned with human atlases and translational goals.
- Scientific Growth & Translation:
- You are excited not only by profiling human immune responses, but also by building experimental systems that capture key features of tissue-specific immunity, including meningeal inflammation and ectopic lymphoid structure-like biology.
- Furthermore, You bring:
- A Ph.D. in Immunol
