Global Head of Pharma Technical Development Synthetic Molecules (PTDC) — Roche

Full description

At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters.

The Position Who We Are

Pharma Global Technical Operations (PT) is the organization that manufactures and delivers Roche’s groundbreaking therapies to millions of patients worldwide. PT is involved in producing every Roche medicine from the development process through clinical trials and continuing to product maturity. Our organization coordinates all aspects of the production of Roche medicines in all disease areas and dosage forms. Pharma Technical Development (PTD) is an integral part of this mission. As an organization of over 2,500 people globally, PTD is responsible for developing the manufacturing processes, products, analytical methods, and Chemistry, Manufacturing & Controls (CMC) strategies to deliver all new products in Roche’s pipeline. This work encompasses the full range of development functions, including biologics, synthetic molecules, devices, clinical supply chain management, and project and portfolio management. PTD applies leading technical expertise to design, develop, supply, and register clinical-stage products globally, reliably delivering the pipeline and supporting commercial manufacturing operations. We excel through innovation, collaboration, dedication, and mutual respect, continuously improving what we do to ensure Roche’s supply of quality products to patients. We commit ourselves to scientific rigor, technical excellence, unassailable ethics, and access to medical innovations for all. We do this today to build a better tomorrow.

Position Purpose

As the Global Head of Pharma Technical Development Synthetic Molecules (PTDC), you are an enterprise leader responsible for the strategic direction, development, clinical manufacturing of Roche’s Synthetic Molecule portfolio. This is a triple-impact role: you lead the end-to-end technical development (CMC) for small molecules, oligonucleotides and peptides, while simultaneously serving as the PTD Basel Site Head . You are also responsible for internal manufacturing of launch and commercial supply of drug substance for the synthetic molecules.

You are the primary accountable leader of the new Synthetic Molecule Facility (SMF), ensuring it is delivered on time and on budget to deliver Pharma Ambition. You act as a catalyst for "Collective Leadership" within PTD, bridging the gap between early-stage innovation and commercial launch excellence.

Key Responsibilities

1. Synthetic Molecule Portfolio & End-to-End Development

• E2E Accountability: Lead the vision and execution for synthetic molecule drug substance, from discovery support and clinical manufacturing to commercial launch and lifecycle management.
• Launch Excellence: Ensure "Right First Time" (RFT) delivery of CMC packages for NMEs (New Molecular Entity) and Line Extensions, directly contributing to Roche's overall goals and R&D Excellence goals.
• Technical Innovation: Drive next-generation synthetic capabilities, including digital automation, "Lab to Plant" models, and sustainable "Green Chemistry" processes.

1. Basel Site Leadership (PTD Site Head)

• Site Governance: Serve as the single point of accountability for all PTD site-related matters in Basel. This includes oversight of Quality, Safety, Sustainability, and Infrastructure.
• Active Basel/Kaiseraugst Management Team member: Effectively representing and advancing PTD and Site interests at the Basel Kaiseraugst Management Meeting.
• People & Culture: Foster a High Performing Organization (HPO). Lead employee training, engagement initiatives, an