Doctoral Student in High-throughput Analysis of Protein-Protein Interactions — ETH Zürich
- Location
- Basel
- Contract
- fixed-term
- Posted
- 4 days ago
Role overview
Doctoral Student in High-throughput Analysis of Protein-Protein Interactions
100%, Basel, fixed-term print Drucken
The Nash Lab (Lab for Engineering Synthetic Systems) is jointly affiliated with the Department of Chemistry at the University of Basel and the Department of Biosystems Science and Engineering of ETH Zurich (located in Basel).
- Doctoral Student in High-throughput Analysis of Protein-Protein Interactions
- 100%, Basel, fixed-term print Drucken
Application process
- We work at the interface of protein engineering, molecular biophysics, and synthetic biology, developing new experimental and computational approaches to understand and engineer proteins for useful biomedical and industrial applications.
- Our research combines high-throughput screening, directed evolution, and single-molecule biophysical methods, and spans projects from fundamental protein science to translational applications. Project background
- Many proteins in the human body experience shear stress and other types of mechanical force, and this is believed to play a central role in their activity.
- Yet we still lack high-throughput techniques to measure how proteins respond to mechanical force.
- This project will develop high-throughput methods involving molecular surface display and deep sequencing to study force-dependent behavior in protein systems.
- These datasets will, in turn, be used to train machine learning models capable of predicting mechanical behaviors of molecular and cellular systems.
- As a proof of concept, we will apply this platform to study interactions central to blood clotting, with direct relevance to Von Willebrand disease, a common bleeding disorder.
- The Doctoral Student will work at the interface of protein engineering, single-molecule biophysics, and machine learning, in close collaboration with a computational biology group (Beerenwinkel) at D-BSSE.
Additional details
- 100%, Basel, fixed-term
- Our research combines high-throughput screening, directed evolution, and single-molecule biophysical methods, and spans projects from fundamental protein science to translational applications. Project background
- The project offers hands-on training across the full pipeline, from high-throughput experimental design to predictive modeling, and the resulting methods and datasets are intended to serve as an open resource for the broader research community.
- Apply next-generation DNA sequencing to quantify phenotypes
- Contribute to undergraduate teaching and practical supervision at the University of Basel
- Willingness to contribute to bachelor level teaching / chemistry practicals Fluent written and spoken English
- Eligibility for enrollment in the D-BSSE Doctoral program in Basel A Doctoral Position with primary supervision by Prof.
Notes and original content
- Our research combines high-throughput screening, directed evolution, and single-molecule biophysical methods, and spans projects from fundamental protein science to translational applications.
- Project background
- Job description
- Willingness to contribute to bachelor level teaching / chemistry practicals
- Fluent written and spoken English
- Eligibility for enrollment in the D-BSSE Doctoral program in Basel
- A Doctoral Position with primary supervision by Prof.
Questions about this listing
What salary does ETH Zürich offer for this role?
ETH Zürich lists CHF 62'000 - 94'000 gross per year for this position in Basel. This is the salary published in the original listing (or, when the employer omits a figure, a realistic estimate for the role and sector) — the calculator on this site converts it to your actual net take-home once cross-border tax and social contributions are applied.
Is this a full-time role, and what type of contract does ETH Zürich offer?
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