Clinical Scientist, Sepsis — Sobi
NewCHF 72'500 - 110'500
Sobi · Basel (BS)
- Location
- Basel
- Contract
- full-time
- Posted
- Yesterday
SalaryCHF 72'500 - 110'500
Role overview
Key Responsibilities and Scope of the Job Responsibilities are listed in order of priority and include, but are not limited to, the following:
- Clinical development strategy and study design
- Provide clinical, scientific and strategic input to clinical development plans for the assigned sepsis programme(s), adhering to the highest scientific and ethical standards.
- Contribute to the definition of the target population, including immune phenotype / endotype and biomarker-based enrichment strategies, and to the selection of clinically meaningful primary and secondary endpoints (for example all-cause mortality at a pre-specified day, organ support-free days, change in organ dysfunction scores).
- Contribute to the evaluation of design options appropriate to acute critical care research, including adaptive, platform and Bayesian approaches, and document the assumptions, effect-size estimates and event-rate expectations on which sample size and feasibility depend.
- Collaborate with the Medical Development Lead (MDL) and Medical Program Lead (MPL) on the overall scientific and medical development strategy.
- Study execution, medical oversight and reporting
- Act as the clinical scientific lead for assigned Sobi-sponsored studies. Where the incumbent holds a medical degree and the responsibility is formally delegated, act as Medical Director / Medical Monitor for those studies.
- Take responsibility for planning, designing, conducting (including medical monitoring) and reporting Sobi-sponsored studies, in close collaboration with Clinical Operations, study teams, Regulatory Affairs, Patient Safety and other cross-functional HQ functions.
- Author clinical study protocols and clinical study reports, and contribute to statistical analysis plans, informed consent templates and other core study documents.
- Support operational feasibility specific to intensive care and emergency department settings, including short screening and treatment windows, out-of-hours randomisation, deferred or emergency consent processes where legally permitted, and biomarker and central laboratory logistics.
- Perform ongoing medical review of emerging safety and efficacy data in a population with high background morbidity and mortality, supporting attribution of adverse events, safety review committee and DSMB interactions, and pre-specified interim analyses.
- Key Responsibilities and Scope of the Job
- are listed in order of priority and include, but are not limited to, the following:
Main responsibilities
- Key Responsibilities and Scope of the Job
- are listed in order of priority and include, but are not limited to, the following:
- Clinical development strategy and study design
- Provide clinical, scientific and strategic input to clinical development plans for the assigned sepsis programme(s), adhering to the highest scientific and ethical standards.
- Contribute to the definition of the target population, including immune phenotype / endotype and biomarker-based enrichment strategies, and to the selection of clinically meaningful primary and secondary endpoints (for example all-cause mortality at a pre-specified day, organ support-free days, change in organ dysfunction scores).
- Contribute to the evaluation of design options appropriate to acute critical care research, including adaptive, platform and Bayesian approaches, and document the assumptions, effect-size estimates and event-rate expectations on which sample size and feasibility depend.
- Collaborate with the Medical Development Lead (MDL) and Medical Program Lead (MPL) on the overall scientific and medical development strategy.
- Study execution, medical oversight and reporting
- Act as the clinical scientific lead for assigned Sobi-sponsored studies.
- Where the incumbent holds a medical degree and the responsibility is formally delegated, act as Medical Director / Medical Monitor for those studies.
Application process
- Contribute high-quality scientific and medical input to the clinical components of regulatory submissions and to responses to Health Authority questions, including scientific advice, IND applications and marketing authorisation applications.
- Maintain current awareness of applicable regulatory guidance and precedent relevant to acute critical care and sepsis trials, and of expedited pathway options where relevant. External scientific engagement
- Interact and consult with key opinion leaders in critical care, infectious diseases and immunology, and support or lead advisory boards to inform development plans for new products and indications.
- Represent Sobi at international conferences and scientific symposia, and support engagement with sepsis-focused scientific societies, research networks and patient advocacy organisations. Cross-functional and business support
- Where assigned, provide scientific and medical expertise to other Sobi functions, including Global Safety, Medical Affairs (advisory boards, scientific communications and publications) and Business Development (due diligence of external compounds, M&A evaluation). Expected ways of working
- Build and maintain a substantive and current knowledge base in sepsis, critical care and immune dysregulation.
- Develop productive working relationships within cross-functional HQ teams, with local affiliates and with collaborative partners.
- Role-model the highest scientific and ethical standards and work in accordance with all applicable rules, regulations and internal procedures governing scientific and medical activities.
Additional details
- Responsibilities are listed in order of priority and include, but are not limited to, the following:
- Participate in investigator meetings, site training and other study-related activities. Regulatory and submission activities
- Maintain current awareness of applicable regulatory guidance and precedent relevant to acute critical care and sepsis trials, and of expedited pathway options where relevant. External scientific engagement
- Represent Sobi at international conferences and scientific symposia, and support engagement with sepsis-focused scientific societies, research networks and patient advocacy organisations. Cross-functional and business support
- Where assigned, provide scientific and medical expertise to other Sobi functions, including Global Safety, Medical Affairs (advisory boards, scientific communications and publications) and Business Development (due diligence of external compounds, M&A evaluation). Expected ways of working
- Education, learning experience and work experience
- Note: medical monitoring and Medical Director accountabilities require a medical degree — see the annex.
- Working knowledge of ICH-GCP, applicable clinical trial regulations and the sponsor obligations attached to protocol design, medical monitoring and study reporting.
- Ability to bring a medical and scientific perspective and drug development judgement to business development, corporate strategy and leadership decision-making. Skills, knowledge and languages
- Professional proficiency in written and spoken English.
Notes and original content
- medical monitoring and Medical Director accountabilities require a medical degree — see the annex.
- Documented record of accomplishment in drug development programmes, demonstrating an in-depth understanding of translating early-stage programmes into the clinic and progressing them across the clinical development chain.
- Working knowledge of ICH-GCP, applicable clinical trial regulations and the sponsor obligations attached to protocol design, medical monitoring and study reporting. Desired
- Clinical or research experience in intensive care medicine, anaesthesiology, infectious diseases, internal medicine or emergency medicine.
- Experience in acute or critical care interventional trials, including mortality-based endpoints, adaptive or platform designs and emergency consent frameworks.
- Understanding of the immunology and pathophysiology of sepsis, including immune dysregulation, hyperinflammatory and immunosuppressed phenotypes, and biomarker-guided patient selection.
- Expertise in pharmacokinetics and pharmacodynamics, including altered PK in critically ill patients (for example capillary leak, altered volume of distribution, renal replacement therapy).
- Ability to bring a medical and scientific perspective and drug development judgement to business development, corporate strategy and leadership decision-making. Skills, knowledge and languages Required
- Strong written and verbal communication skills, with demonstrated ability to represent the company credibly to internal and external audiences, including international conferences, scientific symposia and collaborations.
- Strong organisational and project management skills, with the ability to prioritise across concurrent studies and to act as a self-motivated driver of best practice.
Questions about this listing
What salary does Sobi offer for this role?
Sobi lists CHF 72'500 - 110'500 gross per year for this position in Basel. This is the salary published in the original listing (or, when the employer omits a figure, a realistic estimate for the role and sector) — the calculator on this site converts it to your actual net take-home once cross-border tax and social contributions are applied.
Is this a full-time role, and what type of contract does Sobi offer?
This listing is a full-time position. The contract type shown here comes directly from the employer's original posting; always confirm exact hours, notice period and probation length with Sobi during the application process, since these details can vary by role even within the same contract category.
Do I need a cross-border work permit for a role in Basel?
EU/EFTA residents living in the border zone of the country adjoining Canton Basel can apply for a G permit; the Swiss employer files it with that canton's migration office after the contract is signed. Border-zone rules and processing times vary by neighbouring country and canton, so confirm the specifics with Basel's cantonal migration office or with HR during the application.
How do I apply for this position at Sobi?
Use the "Apply now" button on this page — it links directly to Sobi's original listing at jobs.smartrecruiters.com, so your application goes straight to the employer's own applicant-tracking system. Frontaliere Ticino does not collect or forward applications itself.
