Senior Principal Scientist/Associate Direktor Clinical PBPK (Dual Level Posting) — Novartis
- Ort
- Basel
- Vertrag
- full-time
- Veröffentlicht
- Gestern
Rollenüberblick
Salary Range
CHF122,500.00
CHF227,500.00 Job Description Summary LI-Hybrid
- Salary Range:
- CHF122,500.00
- The candidate’s core responsibilities will include PBPK modeling to integrate in vitro and in vivo data for drug-drug interaction (DDI) assessments, impact of biopharmaceutics properties on absorption, and pharmacokinetic (PK) predictions in humans as well as in specific populations (e.g. disease, organ impairment, pediatrics).
- The ultimate goal of this work is to be on the forefront of applying PBPK models to inform the safe administration of our drug candidates in the clinic, to optimize clinical trial designs, and waive clinical trials, ultimately, to get our medicines to patients faster.
- & Rewards
- At Novartis, we’re committed to reimagining medicine together - and rewarding the people who make it happen.
Hauptaufgaben
- The candidate’s core responsibilities will include PBPK modeling to integrate in vitro and in vivo data for drug-drug interaction (DDI) assessments, impact of biopharmaceutics properties on absorption, and pharmacokinetic (PK) predictions in humans as well as in specific populations (e.g. disease, organ impairment, pediatrics).
- The ultimate goal of this work is to be on the forefront of applying PBPK models to inform the safe administration of our drug candidates in the clinic, to optimize clinical trial designs, and waive clinical trials, ultimately, to get our medicines to patients faster.
- The role requires a deep understanding of ADME/DMPK principles and biopharmaceutics knowledge, experience with industry standard PBPK modeling packages (such as GastroPlus or Simcyp) or bespoke PBPK models, regulatory submissions involving PBPK modeling, interdisciplinary thinking and great attention to detail.
- Expert PBPK modeler to provide translational modeling support for global drug discovery and development projects
- Integrate PK/ PD data, ADME and DDI findings
- Ability to interpret and communicate modeling results and potential impact to project teams
- Prepare summary documents for use in regulatory submissions and ability to respond independently to health authority questions Essential requirements
- PhD in pharmaceutical sciences or related discipline with experience in ADME/DMPK sciences, biopharmaceutics, and modeling and simulation.
- At least 5+ years in pharmaceutical industry including demonstrated knowledge and experience with PBPK modeling.
- The level of the position would depend upon the experience of the candidate.
Was das Unternehmen bietet
- & Rewards
- At Novartis, we’re committed to reimagining medicine together - and rewarding the people who make it happen.
- Expected Annual Base Salary Range for role:
Bewerbungsprozess
- The Modeling & Simulation group within PK Sciences is looking for a Principal Scientist to Associate Director level modeler, to develop and apply translational physiologically based pharmacokinetic (PBPK) modeling along with data analysis techniques to facilitate drug discovery, development, and translational research across disease areas.
- The applicant will work in a dynamic and multidisciplinary environment to build, verify and apply quality translational/biopharmaceutical PBPK models. Job Description Key responsibilities:
- Perform translational PBPK analyses to predict clinical drug exposure in specific populations, assess potential for DDI, understand clinical impact of disease on drug exposure, as well as apply biopharmaceutic PBPK modeling to support formulation changes and achieve clinical biowaivers
Weitere Details
- Job Description Summary
- Internal Title: Senior Principal Scientist or Associate Director Location: Basel, Switzerland
- The applicant will work in a dynamic and multidisciplinary environment to build, verify and apply quality translational/biopharmaceutical PBPK models. Key responsibilities:
- Prepare summary documents for use in regulatory submissions and ability to respond independently to health authority questions Essential requirements
Notizen und Originalinhalt
- CHF227,500.00
- Internal Title: Senior Principal Scientist or Associate Director
- Location: Basel, Switzerland
- The applicant will work in a dynamic and multidisciplinary environment to build, verify and apply quality translational/biopharmaceutical PBPK models.
- Job Description
- Key responsibilities:
- Prepare summary documents for use in regulatory submissions and ability to respond independently to health authority questions
- Essential requirements
- Benefits & Rewards
Fragen zu dieser Stellenanzeige
Welches Gehalt bietet Novartis für diese Stelle?
Novartis gibt CHF 85'500 - 129'500 brutto pro Jahr für diese Position in Basel an. Dies ist das im Original-Inserat veröffentlichte Gehalt (oder, falls der Arbeitgeber keinen Betrag nennt, eine realistische Schätzung für Rolle und Branche) — der Rechner auf dieser Seite berechnet daraus Ihr tatsächliches Netto nach Grenzgänger-Steuer und Sozialabgaben.
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