PostDoctoral Position : Image-Based Drug Screening Against Bacterial Pathogens — EPFL
- Località
- Lausanne
- Contratto
- full-time
- Pubblicato
- Ieri
Panoramica
Mission A postdoctoral position is available in the laboratory of Prof.
Alex Persat (EPFL School of Life Sciences, https://www.p-lab.science/ ) to establish a new image-based drug screening platform targeting gram-negative pathogens ( Klebsiella pneumoniae , Acinetobacter baumannii , Pseudomonas aeruginosa ).
The project will combine single-cell/single-bacterium imaging approaches with the lab's tissue-engineered infection models to identify and characterize compounds active against these priority pathogens.
- Mission A postdoctoral position is available in the laboratory of Prof.
- Alex Persat (EPFL School of Life Sciences, https://www.p-lab.science/ ) to establish a new image-based drug screening platform targeting gram-negative pathogens ( Klebsiella pneumoniae , Acinetobacter baumannii , Pseudomonas aeruginosa ).
- Main duties and responsibilities
- Design and build a microscopy-based phenotypic screening pipeline (live imaging, high-content, single-cell resolution) to assay compound activity
Responsabilità principali
- Main duties and responsibilities
- Design and build a microscopy-based phenotypic screening pipeline (live imaging, high-content, single-cell resolution) to assay compound activity
- Develop imaging assays capable of distinguishing mechanism of action (e.g. growth inhibition, biofilm/attachment disruption, membrane integrity)
- Develop or adapt image analysis and quantification pipelines with AI support to handle screen-scale data
- Follow up on screening hits to identify their molecular target or mechanism of action (e.g. via genetic, chemical-biology, or biophysical approaches), with support from other lab members' expertise in microbiology and drug discovery
- Collaborate with the lab's discovery and design efforts (natural products, AI-enabled molecular design) to feed prioritized targets and hits back into upstream design
Processo di candidatura
- the pipeline to screens in both standard culture and, in collaboration with other lab members, the group's organoid/tissue-engineered infection models (airway, gut) to prioritize physiologically relevant hits
- Co-supervise PhD students and contribute to method development, data management, and grant reporting Profile
- PhD in microbiology, biophysics, bioengineering, or a related field (completed or near completion) with at least a first author publication.
- Hands-on experience with quantitative microscopy (live-cell imaging, high-content screening, or single-cell/single-bacterium imaging)
- Comfort with image analysis pipelines and scripting (Python), experience integrating ML-based image analysis is a plus but not required
- Interest in working across the interface of imaging, microbiology, and drug discovery We offer
- The opportunity to build a new screening platform from the ground up, with significant ownership over pipeline design
- Access to the lab's existing imaging/biophysics infrastructure and tissue-engineered infection model systems
Contatti
- For informal inquiries, contact: [email protected]
Dettagli ulteriori
- details for 3 referees Additional information Contract start date: negotiable A postdoctoral position is available in the laboratory of Prof.
- Apply the pipeline to screens in both standard culture and, in collaboration with other lab members, the group's organoid/tissue-engineered infection models (airway, gut) to prioritize physiologically relevant hits
- Co-supervise PhD students and contribute to method development, data management, and grant reporting
- Interest in working across the interface of imaging, microbiology, and drug discovery
- Support for independent fellowship applications (EMBO, HFSP, MSCA) where relevant Applicants should submit
- A cover letter (PDF, up to 2 pages) describing research interests, achievements and fit A CV with publication list Contact details for 3 referees Additional information Contract start date: negotiable
- Activity Rate : 100.00 Duration: 1 year, renewable
Note e contenuto originale
- A postdoctoral position is available in the laboratory of Prof.
- Support for independent fellowship applications (EMBO, HFSP, MSCA) where relevant
- Informations
- Applicants should submit
- A cover letter (PDF, up to 2 pages) describing research interests, achievements and fit
- A CV with publication list
- Contact details for 3 referees
- Additional information
- Contract start date: negotiable
- Activity Rate : 100.00
Domande frequenti su questo annuncio
Che stipendio offre EPFL per questa posizione?
EPFL indica CHF 60'500 - 91'500 lordi annui per questo ruolo a Lausanne. Questo è lo stipendio pubblicato nell'annuncio originale (o, quando il datore non specifica una cifra, una stima realistica per ruolo e settore) — il calcolatore di questo sito lo converte nel netto reale una volta applicate imposta da frontaliere e contributi sociali.
È un ruolo a tempo pieno, e che tipo di contratto offre EPFL?
Questo annuncio è una posizione a tempo pieno. Il tipo di contratto mostrato qui arriva direttamente dall'annuncio originale del datore di lavoro; conferma sempre orario esatto, preavviso e durata del periodo di prova con EPFL durante il colloquio, perché questi dettagli possono variare anche all'interno della stessa categoria contrattuale.
Serve un permesso da frontaliere per un ruolo nel canton Vaud?
I residenti UE/AELS nella zona di frontiera del paese confinante con il canton Vaud possono richiedere il Permesso G; il datore di lavoro svizzero lo presenta all'ufficio della migrazione di quel canton dopo la firma del contratto. Regole sulla zona di frontiera e tempi di lavorazione variano per paese confinante e canton — verifica i dettagli con l'ufficio della migrazione del canton Vaud o con HR durante il colloquio.
Come mi candido a questa posizione presso EPFL?
Usa il pulsante "Candidati ora" in questa pagina — rimanda direttamente all'annuncio originale di EPFL su careers.epfl.ch, quindi la tua candidatura arriva direttamente nel sistema di gestione candidature del datore di lavoro. Frontaliere Ticino non raccoglie né inoltra candidature in proprio.
