Senior Scientist- SBX Molecular Engineering — Roche

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At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters. The Position We advance science so that we all have more time with the people we love. Roche Diagnostics acquired Stratos Genomics ( https://www.stratosgenomics.com/ ) in 2020 for its unique chemistry that advances DNA sequencing by nanopore, Sequencing by Expansion (SBX™). You will engineer and synthesize the molecular building blocks for our novel technology. These building blocks translate DNA sequences into a simple to measure surrogate, the Xpandomer, which significantly improves the accuracy and throughput of nanopore sequencing. The Molecular Engineering group is passionate about the novel molecules they have developed and the impact SBX technology can have on advancing sequencing and patient outcomes. We are looking for people who are excited about the significance of our technology and want to make SBX successful. The Opportunity:

• Research, design and execute innovative and well-controlled experiments, with high attention to detail.
• Lead, mentor and drive cross functional teams
• Identify and troubleshoot problems in creative ways.
• Contribute to the definition and timely achievement of project goals.
• Develop SOPs to aid in the production of reagents and starting materials
• Participate in the production of reagents and starting materials.
• Perform data analysis and protocol development.
• Maintain accurate, detailed and reliable laboratory records.
• Present findings at group or departmental meetings.
• Maintain the lab’s cleanliness and organization.
• Develop and propose improved processes to fulfill the above functions. Who You Are:
• You have 6 years of laboratory experience in advanced nucleotide/heterocyclic chemistry, phosphorus chemistry and/or complex/multi-step organic synthesis.
• You have a Bachelor’s degree in Organic Synthesis, Chemistry, Chemical Engineering, Biochemistry or a related field and 8 years of experience
• You have a Master’s degree in Organic Synthesis, Chemistry, Chemical Engineering, Biochemistry or a related field and 7 years of experience
• You have a PhD Organic Synthesis, Chemistry, Chemical Engineering, Biochemistry or a related field and 4 years of experience
• Ideally, you will have:
• Demonstrated ability to understand and develop chemistry for:
• Nucleotides
• Phosphoramidites
• Heterocycles
• Amino Acids
• Bio-conjugations
• Mature understanding of how to work with chemical and biochemical samples, including sample handling, reactivity, purification and storage.
• Technical background in next-generation DNA sequencing
• Experience with HPLC, MS, NMR, automated DNA synthesizers, inert atmosphere chambers, and manual pipetting. ​ *Please include a cover letter outlining why you want to work with us, your specific interest in SBX technology and how you would contribute, this is important.* Relocation benefits are available for this posting. The expected salary range for this position based on the primary location of Seattle, WA is $104,400 and $193,800. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed here: Benefits Who we are A healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in m