Senior Principal Scientist/Associate Direttore Clinical PBPK (Dual Level Posting) — Novartis
- Località
- Basel
- Contratto
- full-time
- Pubblicato
- Ieri
Panoramica
Salary Range
CHF122,500.00
CHF227,500.00 Job Description Summary LI-Hybrid
- Salary Range:
- CHF122,500.00
- The candidate’s core responsibilities will include PBPK modeling to integrate in vitro and in vivo data for drug-drug interaction (DDI) assessments, impact of biopharmaceutics properties on absorption, and pharmacokinetic (PK) predictions in humans as well as in specific populations (e.g. disease, organ impairment, pediatrics).
- The ultimate goal of this work is to be on the forefront of applying PBPK models to inform the safe administration of our drug candidates in the clinic, to optimize clinical trial designs, and waive clinical trials, ultimately, to get our medicines to patients faster.
- & Rewards
- At Novartis, we’re committed to reimagining medicine together - and rewarding the people who make it happen.
Responsabilità principali
- The candidate’s core responsibilities will include PBPK modeling to integrate in vitro and in vivo data for drug-drug interaction (DDI) assessments, impact of biopharmaceutics properties on absorption, and pharmacokinetic (PK) predictions in humans as well as in specific populations (e.g. disease, organ impairment, pediatrics).
- The ultimate goal of this work is to be on the forefront of applying PBPK models to inform the safe administration of our drug candidates in the clinic, to optimize clinical trial designs, and waive clinical trials, ultimately, to get our medicines to patients faster.
- The role requires a deep understanding of ADME/DMPK principles and biopharmaceutics knowledge, experience with industry standard PBPK modeling packages (such as GastroPlus or Simcyp) or bespoke PBPK models, regulatory submissions involving PBPK modeling, interdisciplinary thinking and great attention to detail.
- Expert PBPK modeler to provide translational modeling support for global drug discovery and development projects
- Integrate PK/ PD data, ADME and DDI findings
- Ability to interpret and communicate modeling results and potential impact to project teams
- Prepare summary documents for use in regulatory submissions and ability to respond independently to health authority questions Essential requirements
- PhD in pharmaceutical sciences or related discipline with experience in ADME/DMPK sciences, biopharmaceutics, and modeling and simulation.
- At least 5+ years in pharmaceutical industry including demonstrated knowledge and experience with PBPK modeling.
- The level of the position would depend upon the experience of the candidate.
Cosa offre l’azienda
- & Rewards
- At Novartis, we’re committed to reimagining medicine together - and rewarding the people who make it happen.
- Expected Annual Base Salary Range for role:
Processo di candidatura
- The Modeling & Simulation group within PK Sciences is looking for a Principal Scientist to Associate Director level modeler, to develop and apply translational physiologically based pharmacokinetic (PBPK) modeling along with data analysis techniques to facilitate drug discovery, development, and translational research across disease areas.
- The applicant will work in a dynamic and multidisciplinary environment to build, verify and apply quality translational/biopharmaceutical PBPK models. Job Description Key responsibilities:
- Perform translational PBPK analyses to predict clinical drug exposure in specific populations, assess potential for DDI, understand clinical impact of disease on drug exposure, as well as apply biopharmaceutic PBPK modeling to support formulation changes and achieve clinical biowaivers
Dettagli ulteriori
- Job Description Summary
- Internal Title: Senior Principal Scientist or Associate Director Location: Basel, Switzerland
- The applicant will work in a dynamic and multidisciplinary environment to build, verify and apply quality translational/biopharmaceutical PBPK models. Key responsibilities:
- Prepare summary documents for use in regulatory submissions and ability to respond independently to health authority questions Essential requirements
Note e contenuto originale
- CHF227,500.00
- Internal Title: Senior Principal Scientist or Associate Director
- Location: Basel, Switzerland
- The applicant will work in a dynamic and multidisciplinary environment to build, verify and apply quality translational/biopharmaceutical PBPK models.
- Job Description
- Key responsibilities:
- Prepare summary documents for use in regulatory submissions and ability to respond independently to health authority questions
- Essential requirements
- Benefits & Rewards
Domande frequenti su questo annuncio
Che stipendio offre Novartis per questa posizione?
Novartis indica CHF 85'500 - 129'500 lordi annui per questo ruolo a Basel. Questo è lo stipendio pubblicato nell'annuncio originale (o, quando il datore non specifica una cifra, una stima realistica per ruolo e settore) — il calcolatore di questo sito lo converte nel netto reale una volta applicate imposta da frontaliere e contributi sociali.
È un ruolo a tempo pieno, e che tipo di contratto offre Novartis?
Questo annuncio è una posizione a tempo pieno. Il tipo di contratto mostrato qui arriva direttamente dall'annuncio originale del datore di lavoro; conferma sempre orario esatto, preavviso e durata del periodo di prova con Novartis durante il colloquio, perché questi dettagli possono variare anche all'interno della stessa categoria contrattuale.
Serve un permesso da frontaliere per un ruolo nel canton Basilea?
I residenti UE/AELS nella zona di frontiera del paese confinante con il canton Basilea possono richiedere il Permesso G; il datore di lavoro svizzero lo presenta all'ufficio della migrazione di quel canton dopo la firma del contratto. Regole sulla zona di frontiera e tempi di lavorazione variano per paese confinante e canton — verifica i dettagli con l'ufficio della migrazione del canton Basilea o con HR durante il colloquio.
Come mi candido a questa posizione presso Novartis?
Usa il pulsante "Candidati ora" in questa pagina — rimanda direttamente all'annuncio originale di Novartis su novartis.wd3.myworkdayjobs.com, quindi la tua candidatura arriva direttamente nel sistema di gestione candidature del datore di lavoro. Frontaliere Ticino non raccoglie né inoltra candidature in proprio.
